Taking Vitamin D dietary supplements throughout coronavirus an infection useful, dips ranges of cytokine storm: PGIMER meta-analysis

With Covid-19 continuing to affect life, the search for an effective therapy remains elusive. Accordingly, several existing drugs have been repurposed for the treatment of coronavirus infections. In this context, the role of vitamin D, a fat-soluble vitamin mainly related to bone and mineral metabolism in the treatment of Covid-19, has been discussed several times, with some data belittling its role and some studies pointing to its usefulness in Covid – 19th

Given the heterogeneity of the available clinical evidence, an up-to-date systematic review and meta-analysis was conducted by PGI doctors to provide an accurate summary and to compare the effect of vitamin D supplementation on adverse clinical outcomes in Covid-19 patients. The PGI doctors are summarizing the clinical evidence available to date and recently published a study in the Journal of Endocrinological Investigation entitled “Vitamin D Supplementation and Clinical Results in Covid-19: A Systematic Review and Meta-Analysis”.

The study was conducted by Dr. Rimesh Pal, Dr. Mainak Banerjee, Professor Sanjay K. Bhadada, Dr. Anirudh J. Shetty, Dr. Birgurman Singh and Dr. Abhinav Vyas performed. Pooled data from 13 studies and 2,933 Covid-19 patients have shown that vitamin D supplemented after a diagnosis of Covid-19 leads to improved clinical outcomes in terms of reduced mortality and / or ICU admission said Professor Sanjay K. Bhadada, Head of the Department of Endocrinology at PGI.

Professor Bhadada added that vitamin D has helped patients recover better when diagnosing Covid-19, but higher than the standard prescribed dose can result in toxicity and overzealous use of vitamin D must be avoided. “Several mechanisms have been studied, and aside from improved immunity, vitamin D use showed a decrease in the cytokine storm. Since patients are mostly indoors due to the disease, they are not exposed to natural sunlight, ”added Professor Bhadada. He agreed that vitamin D deficiency is high in Indians due to less sun exposure and the color of our skin.

The study supports the fact that vitamin D can be used as an effective adjuvant treatment in patients hospitalized with Covid-19. Vitamin D’s antiviral and immunomodulatory roles may be helpful in this regard. Nevertheless, the irrational and rampant use of vitamin D to prevent Covid-19 must not be the norm. “The use of vitamin D in high doses, especially injectables, for the prevention of Covid-19 should be strongly discouraged. Our meta-analysis found that vitamin D supplemented prior to the diagnosis of Covid-19 did not improve clinical outcomes. Instead, overuse can lead to vitamin D toxicity, ”added Dr. Rimesh Pal added.

Dr. Pal said they went through the studies that were conducted on the subject around the world by June 8 and selected 13 of them – 10 observational and three randomized control studies that were both mortality and mortality Have examined hardcore results before and after diagnosis. “We carried out both adapted and unadjusted analyzes and both led to similar results as the positive effects of vitamin D were increased after the Covid-19 diagnosis,” adds Dr. Pal added.

The present meta-analysis happens to be the most comprehensive pooled data base on vitamin D supplementation for clinical outcomes in Covid-19. In addition, the subgroup analysis showed that the patients who were supplemented with vitamin D after the diagnosis of Covid-19 was more likely to benefit from it than those who were supplemented with the drug before the diagnosis. “In summary, this systematic review and meta-analysis suggests that vitamin D supplementation may be associated with improved clinical outcomes in terms of ICU admission and / or mortality, particularly in patients with moderate to severe disease severe Covid-19 that require hospitalization. However, questions about the appropriate dose, duration and method of administration of vitamin D remain unanswered and offer opportunities for further research, ”concluded Dr. Pal.

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